Application of neighborhood-scale wastewater-based epidemiology in low COVID-19 incidence situationsArticle Published on 2022-12-152022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] application applied approach average characterized Concentration COVID-19 COVID-19 incidence Disease surveillance effective Epidemiology incidence rate infections less limit local outbreak Low COVID-19 incidence Mild N gene Neighborhood-scale sewersheds normalized outbreak plant public health measure quantification reported RT-qPCR SARS-CoV-2 SARS-CoV-2 N gene SARS-CoV-2 variant-specific RT-qPCR assays sensitivity Seven specificity statistically Surveillance the SARS-CoV-2 threshold Treatment virus Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.158448 PMC 바로가기
Impaired immune response drives age-dependent severity of COVID-19Article Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response Aggravated Antiviral benefit caused characterized combinatorial treatment correlation COVID-19 disease disease severity function IFN IFN-γ IFN-λ immune response Immunity Immunotherapy Impaired increasing age individual interferon mice reversed SARS-COV-2 infection severe COVID-19 severe disease severity of COVID-19 susceptibility Therapeutic treatment type I virus replication [DOI] 10.1084/jem.20220621 PMC 바로가기
Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: in vitro characterization, stability, in vitro cytotoxicity, and antiviral activity using real time cell analysisArticle Published on 2022-12-012022-11-15 Journal: Drug Delivery [Category] COVID19(2023년), SARS, 치료제, [키워드] addition administration Analysis Antiviral antiviral activity Calu-3 Cell characterized Concentration COVID-19 cytotoxicity Favipiravir in vitro indicated Influenza virus Inhaled inhaled formulation inhibitor investigated lung lung epithelial cell lung tissue Lungs media Patient patients with COVID-19 PBS phosphate buffer profile pulmonary RdRP real time required respiratory. RNA-dependent RNA polymerase SARS-CoV-2 stability target Toxicity treat Treatment VERO-E6 viability were infected [DOI] 10.1080/10717544.2022.2118398 PMC 바로가기
Sudden unexpected death in a 17-year-old boy due to unacknowledged adamantinoma-like Ewing sarcomaArticle Published on 2022-12-012022-11-15 Journal: Forensic Science, Medicine, and Pathology [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, [키워드] Abnormalities Adamantinoma-like Ewing sarcoma addition airway Airway occlusion Analysis analysis anatomical Autopsy Blood Brain break cardiac cause CD99 Cell characterized Chest radiography Complete death diagnosed diagnostic diagnostics died discharged disease Dyspnea EWSR1 excluded expression Forensic Forensic autopsy forensic pathology Germany histopathological hospital immunohistochemistry Invasion Leica Local lung macroscopic male mechanism Microscopy Mild molecular Nasopharyngeal swab neoplasm nucleoli organ oxygen saturation pathology probe SARS-CoV-2 Soft tissue subject sudden Sudden unexpected death. tested Thyroid was performed [DOI] 10.1007/s12024-022-00525-x PMC 바로가기
SARS-CoV-2 shedding dynamics and transmission in immunosuppressed patients면역 억제 환자의 SARS-CoV-2 발산 역학 및 전파Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjust analysed anatomic site characterized collected conducted coronavirus Diagnosis Diversity dominant E484K first positive fitness genetic change Genome genomic Host hosts household transmission Immunosuppressed immunosuppressed patient immunosuppressed patients in urine in vivo Infection Interaction knowledge long-term viral shedding mother mutate Mutation mutation dynamics N501Y occurred P681R Patient replicate residue residues SARS-CoV-2 SARS-CoV-2 evolution selective Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific treatment Spike protein spread to Substitution temporal dynamics Transmission two patients Urine variant variant of concern variants variants of concern virus whole genome Whole genome sequencing whole genome sequencing. whole-genome sequencing [DOI] 10.1080/21505594.2022.2101198 PMC 바로가기 [Article Type] Article
Planetary health & COVID-19: A multi-perspective investigationReview article Published on 2022-12-012022-10-05 Journal: One Health [Category] 신약개발, [키워드] characterized complex COVID-19 driver Drivers growth Health Impact implication Implications indicate influence literature review outcome Planetary health public health SDGs spread of COVID-19 Stress wet markets [DOI] 10.1016/j.onehlt.2022.100416 [Article Type] Review article
Association of iron-related biomarkers with severity and mortality in COVID-19 patientsArticle Published on 2022-12-012022-11-15 Journal: Journal of trace elements in medicine and biology [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] Activation Analysis analyzed association AUC biological processes Biomarker can be used characterized Combination continuous monitoring contribute Control controls Course COVID COVID 19 COVID-19 COVID-19 patient cutoff point Deceased decrease deficiency demonstrated discharged ferritin healthy individual highest IL-6 immune responses immune system immunomodulatory individual infected with COVID-19 Infection Inflammation iron marker material Mild moderate Mortality multiple regression model outcome oxidative stress parameter patients with COVID-19 receiver operating characteristic recruited regulate required ROC ROC Curve SARS-CoV-2 patients sensitivity serum severe disease severity shown significant difference significantly significantly increased specificity stepwise AIC selection survival susceptibility the cytokine storm the median trace Trace element Trace metals Transferrin Transferrin. variable variety viral infections [DOI] 10.1016/j.jtemb.2022.127075 PMC 바로가기
Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters시리아 골든 햄스터에서 SARS-CoV-2 Omicron BA.1(B.1.1.529) 변종 접종 후 폐 병변Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] animals B.1.1.529 B.1.617.2 characterized Clinical signs COVID-19 disease decrease Delta Disease progression disease severity evaluate Evidence evidence of golden hamster hamster hamsters histopathological Human Immune escape Immunity Infection inoculated intrinsic Kinetics lesion Mutation omicron Omicron BA.1 pathogenicity pathological changes pathology Pneumonia pre-existing immunity progression pulmonary re-challenge. reduced SARS-CoV-2 SARS-CoV-2 variant Syrian golden hamster the SARS-CoV-2 vaccination variant viral genome viral shedding viral spread virus [DOI] 10.1080/22221751.2022.2095932 PMC 바로가기 [Article Type] Article
Tracking SARS-CoV-2 in rivers as a tool for epidemiological surveillanceArticle Published on 2022-11-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activities analysis Bacteria Caldera can be used characterized collected Concentration Contamination contributed correlated correlation COVID-19 COVID-19 cases discharge epidemiological epidemiological situation epidemiological surveillance evaluate fecal health authorities Human Human tracers impacted limit microbiologically negatively affected normalization normalized not affected plant quantified receiving reflected reported river Rivers impacted by wastewater RNase P RT-qPCR Salta SARS-CoV-2 SARS-CoV-2 surveillance significant increase similarity Support Surveillance target Viral concentration water quality water quality. [DOI] 10.1016/j.scitotenv.2022.157707 PMC 바로가기
Antigenic mapping reveals sites of vulnerability on α-HCoV spike proteinArticle Published on 2022-11-042022-11-15 Journal: Communications Biology [Category] SARS, 진단, [키워드] antigenic appear characterized conserved distal domain dominant effective epitope Epitopes feasibility HCoV-229E HCoV-NL63 highlight human coronavirus imperative N-terminal domain Neutralizing neutralizing antibody panel of antibody Protein RBD Receptor binding domain receptor binding site recognize representing reveal S protein S proteins similarity spike Spike protein subset the SARS-CoV-2 understanding Vaccine design Vaccine development [DOI] 10.1038/s42003-022-04160-8 PMC 바로가기